Histological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth

Abstract The aim of the study was to evaluate inflammatory tissue reactions and formation calcified after implantation experimental nanostructured calcium silicate cement (CS) hydroxyapatite with (HA-CS) into root canals rabbits’ teeth. conducted on four rabbits genus Oryctolagus cuniculus. After instrumentation irrigation, central incisors were dried filled CS, HA-CS control material (MTA Angelus). animals sacrificed 28 days. histological preparation hematoxylin-eosin staining, samples evaluated for intensity extension reaction; continuity, morphology thickness newly formed tissue; presence giant cells, materials particles microorganisms. Kruskal Wallis Dunn’s post hoc test used data analysis (α=0.05). There no significant differences in between MTA control. showed significantly better results than CS respect continuity (P=0.003 P=0.010, respectively). Significant existed (P=0.004) (P=0.012). Application resulted minimal response, similar more efficient supporting hard formation. best organized seen application.